Title: Baicalin attenuates kainic acid-induced neuronal cell death in the hippocampus of mice
Abstract: Objective To study the protective effect of baicalin against kainic acid(KA)-induced hippocampus oxidant injury and neuronal cell death in mice.Methods Thirty-six ICR male mice were randomly divided into three groups: control,model and baicalin intervention group(n=12 each).To establish animal model of status epilepticus,0.1 μg/5μl kainic acid was injected into the intracerebroventricular of the mice.The expression of gonadotrophic stimulating hormone(GSH) and the superoxide dismutase(SOD) activity in the hippocampus were detected by spectrophotometry.The content of malondialdehyde(MDA) in the hippocampus was examined by thiobarbituric acid reactive substance assay(TBARS).Neuronal cell death in the hippocampus was determined by nissl staining 24 hrs after kainic acid injection.Results Kainic acid caused an increase in the MDA content and neuronal cell death and a decrease in the GSH expression and the SOD activity in the hippocampus.Baicalin treatment attenuated the degree of lipid peroxidation and neuronal cell death and increased the GSH expression and the SOD activity in kainic acid treated mice.Conclusions Baicalin may attenuate kainic acid-induced neuronal cell death in mice by increasing GSH expression and SOD activity and decreasing MDA content in the hippocampus.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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