Title: The Role of Histone Acetylation/Disacetylation in Eucaryote Gene Transcription Regulation
Abstract: In encaryote, nucleosome is the basic unit of chromosome, and it is composed of central histone octamer, which is made up of H 2A, H 2B, H 3, H 4 and DNA that bind it. Materials show that the central histone could affect transcription both in vivo and in vitro. The recent research shows that the process of acetylation and disacetylation is the key of regulating genes' activity. While there are two kinds of molecules that contain the disacetylase's activity: one is the homology with yeast RPD3, another one is not. They have the different sources, exist in the respective composite and catalyze different histone or the protein disacetylation. These all have close relationship with gene transcription regulation; especially it's inhibitory action. ;
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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