Title: Evaluation of the Anti-proliferative Activities of Major Fruits in China on Human Hepatic Carcinoma(HepG2) and Colon Adenocarcinoma(Caco-2) Cells
Abstract: The total phenolic content and the anti-proliferative activities of the phenolic extracts against Hep G2 and Caco-2 cells were determined by the Folin-Ciocalteu method and the methylene blue assay, respectively; the correlation between the total phenolic content and the anti-proliferative activity of the extracts was analyzed. The results of these analyses revealed that plum(Prunus salicina Lindl.) had the highest total phenolic content(1686.08 ± 96.94 μmol gallic acid equivalent(GAE)/100 g of fresh fruit), whereas watermelon(Citrullus lanatus)(83.54 ± 2.10 μmol GAE/100 g of fresh fruit) and hami melon(Cucumis melo var. saccharinus)(79.35 ± 0.76 mol GAE/100 g of fresh fruit) had the lowest phenolic content among the 25 tested species. Among the fruit species with quantifiable anti-proliferative activities(half maximal effective concentration(EC50)), plum and guava(Psidium guajava Linn.) showed the strongest anti-proliferative activities against Hep G2 cells(EC50 values: 18.99 ± 0.06 and 20.94 ± 0.09 mg/m L, respectively), whereas pears(Pyrus spp.) showed the weakest anti-proliferative activity against these cells(EC50 value: 389.63 ± 10.82 mg/m L). Plum also demonstrated the strongest anti-proliferative activity against Caco-2 cells(EC50 value: 8.73 ± 0.11 mg/m L), while the activity of pitava(Hylocereus undulatus Britt.) was observed to be the weakest(EC50 value: 388.07 ± 7.04 mg/m L). The anti-proliferative activities of fruits on Hep G2 and Caco-2 cells were significantly correlated to their total phenolic content(R2 = 0.4147, p 0.01; R2 = 0.4071, p 0.05, respectively). This correlation indicates the high anti-proliferative effect of fruit polyphenols on cancer cells.
Publication Year: 2015
Publication Date: 2015-01-01
Language: en
Type: article
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