Title: Research about the expression of VEGF-C,CXCR4 and MLVD in thyroid neoplasm
Abstract: Objective To investigate the expression of VEGF-C,CXCR4 and micro-lymphatic vessel density(MLVD) in thyroid neoplasm.Methods The expression of VEGF-C,CXCR4 and MLVD in 100 paraffin-embedded thyroid carcinomas and 20 thyroid adenomas were studied by immunochemical methods.Results Expression of VEGF-C and CXCR4 in the group of thyroid carcinoma and thyroid carcinoma with lymph node metastasis were significantly different from that in the group of thyroid adenoma and thyroid carcinoma without lymph node metastasis;In different pathological category,clinical stage and life span,the expression of VEGF-C and CXCR4 was significantly different.MLVD in the three group of thyroid carcinoma with lymph node metastasis,without lymph node metastasis and thyroid adenomas were significantly different.VEGF-C was correlated with MLVD.Conclusion VEGF,CXCR4 and MLVD can be regarded as valuable molecular markers to distinguish malignant tumor from benign one,to tell whether there are lymph node metastasis or not and to estimate the prognosis.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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