Title: Effects of combined therapy with losartan and hydrochlorothiazide in hypertensive patients with hyperuricemia
Abstract: Objective:To evaluate the effects of losartan and hydrochlorothiazide combination therapy on blood pressure and serum uric acid levels in hypertensive patients with hyperuricemia.Methods:A cohort of 55 patients with hypertension and hyperuricemia whose blood pressures uncontrolled with losartan(100 mg/d)for more than 4 weeks were enrolled in this study.All patients were prescribed combination therapy of losartan(50 mg/d)and hydrochlorothiazide(12.5 mg/d)for12 weeks.Blood pressures and serum uric acid levels were determined before and after adjustments to the therapy. Results:After losartan and hydrochlorothiazide combination therapy,mean systolic and mean diastolic pressures decreased significantly,which were(148±11)mmHg vs.(133±14)mmHg and(91±8)mmHg vs.(84±9)mmHg(P0.001),and no significant change in serum uric acid levels was observed at the end of the treatment. Conclusion:For hypertensive patients with hyperuricemia,combination of losartan and hydrochlorothiazide is more effective in reducing blood pressure than losartan single treatment and has no significant influence on serum uric acid levels.
Publication Year: 2015
Publication Date: 2015-01-01
Language: en
Type: article
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