Title: Clostridia in the gut and onset of atopic dermatitis via eosinophilic inflammation
Abstract: The balance of commensal and pathogenic microbiota in the intestine plays an important role in immune system development through the establishment of gastrointestinal epithelial barriers and immune system homeostasis. [1] Peterson L.W. Artis D. Intestinal epithelial cells: regulators of barrier function and immune homeostasis. Nat Rev Immunol. 2014; 14: 141-153 Crossref PubMed Scopus (1660) Google Scholar Alterations to this balance may cause systemic chronic inflammation and may lead to the development of allergic diseases. [1] Peterson L.W. Artis D. Intestinal epithelial cells: regulators of barrier function and immune homeostasis. Nat Rev Immunol. 2014; 14: 141-153 Crossref PubMed Scopus (1660) Google Scholar Studies on the association between gut microbiota in early life and atopic dermatitis (AD) led to inconclusive results with a poor mechanistic understanding. 2 Penders J. Stobberingh E.E. Thijs C. et al. Molecular fingerprinting of the intestinal microbiota of infants in whom atopic eczema was or was not developing. Clin Exp Allergy. 2006; 36: 1602-1608 Crossref PubMed Scopus (99) Google Scholar , 3 Watanabe S. Narisawa Y. Arase S. et al. Differences in fecal microflora between patients with atopic dermatitis and healthy control subjects. J Allergy Clin Immunol. 2003; 111: 587-591 Abstract Full Text Full Text PDF PubMed Scopus (284) Google Scholar , 4 Penders J. Gerhold K. Stobberingh E.E. et al. Establishment of the intestinal microbiota and its role for atopic dermatitis in early childhood. J Allergy Clin Immunol. 2013; 132: 601-607.e608 Abstract Full Text Full Text PDF PubMed Scopus (208) Google Scholar , 5 Abrahamsson T.R. Jakobsson H.E. Andersson A.F. Bjorksten B. Engstrand L. Jenmalm M.C. Low diversity of the gut microbiota in infants with atopic eczema. J Allergy Clin Immunol. 2012; 129 (440.e431–432): 434-440 Abstract Full Text Full Text PDF PubMed Scopus (578) Google Scholar , 6 Nylund L. Nermes M. Isolauri E. Salminen S. de Vos W.M. Satokari R. Severity of atopic disease inversely correlates with intestinal microbiota diversity and butyrate-producing bacteria. Allergy. 2015; 70: 241-244 Crossref PubMed Scopus (146) Google Scholar
Publication Year: 2016
Publication Date: 2016-07-01
Language: en
Type: letter
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 63
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