Title: Treatment of mild influenza A virus(H1N1) patients with Treaditional Chinese Medicine
Abstract: Objective To observe the clinical efficacy and mechanism of traditional Chiese Medicine(TCM) in treating influenza A(H1N1).Methods With randomized controlled trial,168 mild influenza A H1N1 patients divided into treatment group and control group.The treatment group were randomly divided into treatment group and control group.The treatment group was interfered with Chinese medicine and support therapy for seven days.While the control group were interfered with oseltamivir and support therapy.The disappearance time of cardinal symptom and virus nucleic acid shade time were documented before and after treatment.The serum levels of IL-6,INF-αand TNF-αbefore and after treatment were recorded.The cost of every therapeutic effect was evaluated by the cost-effect ratio in the two treat schemes.Results The ORR of treatment and control group was 100%,the cure rate were 94.48% and 91.67% respectively.The disapearance time of cough,headache,muscular stiffness and weak in the treatment group were less than control group significantly(P0.05).Virus nucleic acid shade time in treatment group(5.2±0.8 d)was less than that of control group(4.5±0.6 d) significantly(P0.05).The serum levels of IL-6,INF-αand TNF-αdecreased significantly after treatment,but there were no significant difference between two groups.The cost-effect ratio in the treatment group(10.2±1.6) was less than the control group(15.5±2.3).Five patients with adverse reaction were found in the control group(5.95%,5/84),While there was no adverse reaction found in the treatment group.Conclusions The treatment ofinfluenza A(H1N1)with traditional Chinese medicine recover more fastly,with less adverse reaction and cost,which may inhibit replication of virus and regulating body immunity function.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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