Title: Influence of Anisodamine on neuronal apoptosis after cerebral ischemia reperfusion in the rats
Abstract: Objective The number of surviving neuron,TUNEL positive neuron,HSP70 positive neuron and the ultrastructure of the CA1 subfield of hippocampus was detected after the cerebral ischemia reperfusion of rats and the protective effects of anisodamine(Ani) were also observed.Methods Pulsinelli’s method was employed to establish cerebral ischemia-reperfusion animal models.Observing the influence of Ani on the number of surviving neuron,TUNEL positive neuron,HSP70 positive neuron and ultrastructure of the CA1 subfield of hippocampus.Results Ani could induce upregulation of HSP70 expression after cerebral ischemia reperfusion.Neuronal apoptosis after cerebral ischemia reperfusion was decreased and the surviving number of pyramidal cells in hippocampus CA1 was increased by Ani. Conclusion Ani have a remarkable protection on cerebral ischemia reperfusion damage.Its mechanism may be related with decreasing the neuronal apoptosis.
Publication Year: 2001
Publication Date: 2001-01-01
Language: en
Type: article
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