Title: Clinical treatment of the severe hepatitis with intravenous human immunoglobulin
Abstract: Objective To investigate the effective drug for the treatment of various reasons severe hepatitis and study the clinical value of human intravenous immunoglobulin(IVIG) in the treatment of severe hepatitis, assess security of IVIG drug. Methods Among 62 patients with severe hepatitis, the treatment group and the control group were composed by 30 and 32 patients, respectively. The control group was treated with rest, energy supplement, regulate water electrolyte and acid-base balance, the hepatoprotective, plasma, protein, comprehensive treatment. The treatment group was given IVIG intravenous on the basis of the control group, each 5 g, once a day for five times. Before and after treatment, the routine of blood, urine and stool were tested. The liver and kidney function, cardiac enzymes, blood biochemistry were detected by automatic biochemical analyzer. The cruor four kinds of projects(PT, APTT, TT and FIB) were detected by automatic coagulation analyzer. The above indicators observation time was six weeks. Survived cases were followed up for 3 months. Results After treatment, the two groups were with significant differences at blood biochemistry(TBil, PT, PA and CHE)(P all 0.05). In treatment group, there were 24 cases were effective, with the efficiency of 80.00%. In control group, there were 12 cases were effective, with the efficiency of 37.50%. The efficiency in the two groups was with significant differences(P 0.01). The improvement rate of the treatment group significantly higher than that of control group. Adverse reactions: in treatment group there was one case with chest tightness, mild shortness of breath, symptoms disappeared after symptomatic treatment, accounting for 3.33%. Conclusions IVIG treatment of various reasons severe hepatitis is effective, a variety of biochemical indicators of severe hepatitis patients can improve. Followed up for 3 months, IVIG significantly improved healing rate of patients with severe hepatitis. Adverse reactions are rare and mild. IVIG is effective and security drug for the treatment of severe hepatitis.
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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