Title: Effects of dexmedetomidine on stress response in patients under epidural anaesthesia
Abstract: Objective This study was to observe the effects of dexmedetomidine on stress response in patients under epidural anesthesia.Methods Sixty patients,male 32 and female 28,ASAⅠ orⅡ,undergoing lower extremity surgery under epidural anesthesia were randomly divided into the dexmedetomidine group(group D),the midazolam group(group M),and the propofol group(group P).In group D,patients received intravenous 1μg/kg dexmedetomidine for 10 min after anesthesia,and 0.5μg·kg-1·h-1 dexmedetomidine infusion till the end of surgery.Patients in group M received 0.05mg/kg midazolam,while patients in group P received 1mg/kg propofol and a 2mg·kg-1·h-1 infusion.The MAP,HR,AAI were recorded before the administration of drugs(T0),10 min(T1),30min(T2)and 60min(T3)after the administration,and at the end of surgery(T4).The expression of plasma cortisol was measured at T0 and T4.Results Compared with T0,AAI and MAP in the three groups at T1-T4 were significantly decreased(P0.05 or P0.01).AAI in group P at T3 was lower than that in groups D and M(P0.05),MAP in groups D and P at T2-T4 was lower than those in group M(P0.05),HR in groups D and R at T3 and T4 was slower than those at T0 and group M(P0.05).Compared with T0,the expression of cortisol was decreased at T4 in the three groups.Compared with group D,the expression of cortisol was increased in groups P and M at T4(P0.05).Conclusion Dexmedetomidine,as an adjuvant for epidural anesthesia,may has an effect on reducing the stress response.
Publication Year: 2015
Publication Date: 2015-01-01
Language: en
Type: article
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