Title: Clinical Significance of Circulating Tumor Cells Detection in Non-small Cell Lung Cancer Patients
Abstract: Objective To investigate the clinical significance of circulating tumor cells(CTC) in patients with advanced non-small cell lung cancer(NSCLC).Methods 30 patients with advanced NSCLC admitted to the First Affiliated Hospital of Shihezi University Medical College from June 2011 to February 2012 were selected as cancer group,while 10 patients with benign lung disease and 10 healthy people were also selected as control group.The CTC expression of peripheral blood in the two groups before and after chemotherapy was detected by density gradient centrifugation method and immunofluorescence method,and its relationship with clinical features and curative effect was analyzed.Results There was no positive cell in peripheral blood in the control group,while there were positive cells in 18 cases in the cancer group(60%),and the CTC positive rate between the two groups showed statistically significant difference(P = 0.001).Positive CTC showed no correlation with the age,gender,smoking,organization type and degree of differentiation(P 0.05),but showed correlation with clinical stages(P 0.05).Before chemotherapy,18 cases were positive(positive rate was 60%),while after chemotherapy,11 cases were positive(positive rate was 37%),and the difference was statistically significant(P 0.05).The evaluation of therapeutic effects after two cycles of chemotherapy through imaging and circulating tumor cells' number showed that the two kinds of evaluation methods had no statistically significant difference(χ2= 7.000,P 0.05),and had a certain degree of fit(κ = 0.577).The correlation analysis showed that the number of CTC was correlated with the clinical efficacy(r =-0.434,P = 0.017).Conclusion The CTC positive rate is correlated with clinical stage,as well as curative effect.The number of CTC can predict the effects of chemotherapy in advanced NSCLC.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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Cited By Count: 1
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