Title: Mechanism of the Reversal Effect of Losartan on Left Ventricular Remodeling in Spontaneously Hypertension Rate(SHR)
Abstract: Objective:To investigate the relationship between the reversal effects of Losartan on the left ventricular remodeling and the effects of myocardiac Angiotensin Ⅱ (AngⅡ) level,endothelial function and intracellular calcium metabolism in SHR. Method:Twenty one spontaneously hypertensive rats (SHR) were randomly distributed to 3 groups:3 month control group (SHR C3),6 month control group (SHR C6) and Losartan group (SHR L). The 3 monthage SHRs from Losortan group were treated with Losortan(20 mg/kg·d -1 ) until the rats were 6 month by age.SBP,LVMI,plasma and myocardiac AngⅡ,serum Nitric Oxide(NO),plasma Endothelin(ET),peripheral lymphocyte cytosolic calcium([Ca 2+ ]i) were assessed before and after treatment. Results:Compared with WKYs,the SBP,LVMI,Plasma and myocardiac AngⅡ,ET,[Ca 2+ ]i were all significantly greater but NO was significantly less in SHRs.The difference between SHRs and WKYs became more prominent when they grew older. The SBP,LVMI,myocardiac AngⅡ,ET and [Ca 2+ ]i were all significantly decreased but NO was significantly increased in SHRs after Losartan therapy. Conclusions:Losartan can reverse the left ventricular remodeling not only by blocking AT 1 receptor but also by lowering tissue Ang Ⅱ,improving endothelial function and correcting the disorder of intracellular calcium metabolism.
Publication Year: 2002
Publication Date: 2002-01-01
Language: en
Type: article
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