Title: The expression and clinical significance of serum miR-200a in patients with hepatocellular carcinoma
Abstract:Objective To investigate the expression level of miR-200a in serum of patients with hepatocellular carcinoma and its clinical significance. Methods Real time PCR was used to detect the expression of m...Objective To investigate the expression level of miR-200a in serum of patients with hepatocellular carcinoma and its clinical significance. Methods Real time PCR was used to detect the expression of miR-200a in the serum of 36 patients with hepatocellular carcinoma and 21 normal controls, to analysis the relationship between the expression of serum miR-200a and clinical pathological parameters in patients with hepatocellular carcinoma. The AFP expression was got from clinical data. Results The expression level of miR-200a was 4.63 ±1.31 in 36 hepatocellular carcinoma patients and 6.05±0.51 in 21 normal control.Serum miR-200a expression level in 36 patients was significantly lower than that in normal control(P0.05). Serum miR-200a expression was significantly associated with tumor differentiation, TNM and AFP(P0.05). There were no correlation between serum miR-200a expression level and sex, age, smoked cigarettes, consumed alcohol, HBV, cirrhosis(P0.05). Conclusion Our data confirms a role for serum miR-200a as a novel cancer biomarker in hepatocellular carcinoma.Read More
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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