Title: Effects of atorvastatin on adrenomedullin receptor expression in renal cortex of diabetic rats
Abstract:Objective To investigate the change of adrenomedullin receptor (ADMR) in nephropathy of diabetic rats and the effects of atorvastatin on the expression of ADMR mRNA and protein. Methods The SD rats we...Objective To investigate the change of adrenomedullin receptor (ADMR) in nephropathy of diabetic rats and the effects of atorvastatin on the expression of ADMR mRNA and protein. Methods The SD rats were divided into three groups: normal rats, streptozotocin (STZ)-induced diabetic rats and diabetic rats treated with atorvastatin. STZ-induced diabetic rats were treated with atorvastatin (15 mg/kg body weight) or vehicle for 8 weeks. ADMR mRNA expression was assessed by RT-PCR, and ADMR protein expression was measured by Western blot analysis in renal cortex of rats. Results (1) As compared with diabetic rats without atorvastatin treatment, the 24 h urinary albumin excretion in diabetic rats treated with atorvastatin was reduced [(35.9±1.7)μg/24 h vs (19.8±1.5)μg/24 h, P0.05], but no significant difference was shown in HbA_(1C), blood glucose and body weight between the two groups. (2) The expressions of ADMR mRNA and protein were increased in the renal cortex of diabetic rats treated with atorvastatin as compared with diabetic rats without atorvastatin treatment (both P0.05). Conclusion Atorvastatin treatment can improve renal function of diabetic rats, suggesting that the beneficial effect might be mediated by ADMR.Read More
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot