Title: Effects of edaravone associate with ulinastatin on cerebral protection in patients undergoing cardiac valve replacement
Abstract: Objective To investigate the effects of edaravone associate with ulinastatin on cerebral protection in patients undergoing cardiac valve replacement under cardiopulmonary bypass(CPB).Methods Forty patients undergoing selective cardiac valve replacement under CPB were randomly divided into four groups with 10 cases each.In group E,edaravone 0.5 mg/kg was infused in the period of anesthesia induction and thoracotomy.In group U,ulinastatin 12000U/kg was injected IV.In group EU,edaravone associate with ulinastatin were given as in groups of E and U.In group C,isometric normal saline was given instead of edaravone and ulinastatin.Right internal jugular vein was cannulated and the catheter advanced cephalad to the glomus jugulare for blood samples.Gather blood specimen and the plasma concentrations of MDA,TNF-α,IL-6,IL-10,S-100β protein,NSE and SOD,T-AOC activity were measured at the time between the period of anesthesia induction and administration(T0),10 min after aortic unclamping(T1),4 h(T2) and 24 h(T3).Postoperative neuropsychological complications were observed.Results Compared to group C,at T1,T2 plasma concentrations of TNF-α,IL-6,MDA,S-100β protein and NSE were lower,and IL-10,SOD and T-AOC were higher in groups of E,U and EU(P0.05).Compared to group E,plasma concentrations of TNF-α,IL-6 were lower,MDA and IL-10 were higher in group U,TNF-α,IL-6,S-100β protein and NSE were lower,IL-10 was higher in group EU(P0.05).Compared to group U,TNF-α,IL-6,MDA,S-100β protein and NSE were lower,IL-10 was higher in group EU(P0.05).No delirium and neural positive signs were appeared.Conclusion Compared with use of edaravone or ulinastatin alone,edaravone combined with ulinastatin has better efficacy in alleviating brain injury in patients undergoing cardiac valve replacement under CPB by restraining cascade amplification among inflammatory factors,oxyradica and cytokines.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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