Title: MSCT myocardial perfusion and coronary angiography in dog acute myocardial infarction model
Abstract: Objective: To study myocardial perfusion in acute myocardial infarction with MSCT, and to explore the value of MSCT coronary angiography in demonstrating coronary artery blockage. Methods: The left anterior descending artery (LAD) was ligated in healthy dogs and MSCT perfusion scans were done in several stages. The perfusion peculiarity was analyzed and compared with pathological findings. MSCT coronary angiography was done before and after LAD ligated. Results: The normal mean myocardial perfusion was (69.3±13.9) ml·100 g-1·min-1; the mean time to peak (TTP) was (12.8±2.1) sec. After LAD was ligated, the myocardial perfusion became significantly lower than normal, and Time Density Carve became flat. In delayed 10 seconds scans, there was no significant difference between normal myocardium and the myocardium after LAD ligated for 30 seconds, but significantly high enhancement was found after LAD tied for 4 h. MSCT coronary angiography showed the blockage of LAD. Conclusion: MSCT myocardial perfusion combined with coronary angiography can estimate myocardial ischemia and infarction and show the blockage of the coronary artery.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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