Title: The correlation of nm23H1,VEGF expression with tumor metastasis and survival rat e in prostate cancer
Abstract: Objective To study the expressions of non- metastatic gene 23H1 (nm23H1) and vascular endothelial growth factor (VEGF) in p rostate cancer tissues and to explore their relationship with tumor development, tumor metastasis and patients’ survival rate. Methods U sing immunohistochemical method,41 prostate cancer specimens and 10 normal tissu e specimens (controls) were tested for expressions of nm23H1 and VEGF.Using CD31 for marking vascular endothelial cell,the tumor microvessel density (MVD) was calculated and the patients’ survival rate after operation was investigated.The correlation of nm23H1,VEGF expression and MVD with TNM staging,pathologic gradi ng and bone metastasis was analyzed in combination with the clinical data. Results The positive expression rates of nm23H1 and VEGF in p rostate cancer were 70.7%(29/41)and 68.3% (28/41),while they were 10.0% (1/10) and 30.0%(3/10)in controls, indicating significant difference between them ( P0.01).The mean MVD in prostate cancer tissue was 75.1±12.9/mm2,while it was 32.1±8.5/mm2 in the controls (P0.01).With positive expression of nm 23H1,the bone metastasis rate was low,while with negative expression of nm23H1,t he bone metastasis rate was high.The difference was statistically significant ( P0.01).Patients with positive VEGF expression had higher bone metastasis ra te, while those with negative VEGF expression had no bone metastasis. The differ ence was statistically significant (P0.01).The higher the nm23H1 expression , the higher the survival rate.By contrast, the higher the VEGF expression, the lower the survival rate. Conclusions Gene nm23H1 can sup press prostate cancer development and metastasis,therefore,improve the survival rate. High VEGF expression in prostate cancer can promote the forming of blood a nd lymphatic vessels,causing tumor metastasis, which can reduce the survival rat e.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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