Title: Effect of Xiongma Drop Pill on the Metabolism of Cholinergic Neurotransmitter in Vascular Dementia Rats
Abstract: Objective To investigate the effects of Xiongma Drop Pill (XMDP) on the metabolism of cholinergic neurotrans- mitter in vasculer dementia rats and to explore its possible therapeutic mechanism.Methods The vascular dementia(VD) mod- el of rats was established by permanent occlusion of bilateral common carotid arteries(2-VO).The level of acetylcholine (Ach),activities of acetylcholinesterase (AchE) and choline acetyhransferase (CHAT) in brain tissue were detected by UV- spectrophotometer.Results Compared with sham-operation group,the level of Ach decreased in the model group (P0.001),and activity of ChAT decreased (P0.05),but the difference of Ache activity was insignificant.Compared with the model group,the middle-dose XMDP and the low-dose XMDP increased the level of Ach content and ChAT activity (P0.05),but the difference of Ache activity was insignificant.Conclusion The mechanism of Xiongma Drop Pill in treating vascular dementia may be related to the reduction of Ach level and ChAT activity in brain tissues of vascular dementia rats.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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Cited By Count: 2
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