Title: Expression of Vascular Endothelial Growth Factor C and D and Their Receptor in Serum of Patients with Cervical Carcinoma and Their Clinical Significance
Abstract: Objective To detect vascular endothelial growth factor C and D(VEGF-C and VEGF-D) and their receptor-3(VEGFR-3) levels in serum of patients with cervical cancer,and to explore the correlation of lymph node metastasis with VEGF-C,VEGF-D and VEGFR-3.Methods ELISA was used to detect the expression levels of VEGF-C,VEGF-D and VEGFR-3 in serum of 10 cases of normal cervical tissues,36 cases of cervical intraepithelial neoplasia Ⅲ(CINⅢ group),33 cases of cervical cancer without lymph node metastasis,10 cases of cervical cancer with lymph node metastasis.The difference of expression levels of VEGF-C,VEGF-D and VEGFR-3 were compared among different groups.Results(1)The expression levels of VEGF-C,VEGF-D and VEGFR-3 in serum of cervical cancer patients without lymph node metastasis were significantly higher than those in normal cervical tissues group and CINⅢ group(P0.05);(2)The expression levels of VEGF-C,VEGF-D and VEGFR-3 in serum of cervical cancer patients with lymph node metastasis were significantly higher than those in cervical cancer patients without lymph node metastasis(P0.05);(3)There was no significant difference in expression levels of serum VEGF-C,VEGF-D and VEGFR-3 between CINⅢ group and normal cervical tissues group(P0.05).Conclusion The expression levels of VEGF-C,VEGF-D and VEGFR-3 are related to lymph node metastasis in patients with cervical cancer,and the expression levels of VEGF-C and VEGF-D are closely related to that of VEGFR-3.Thus,VEGF-C and VEGF-D may increase the incidence of lymph node metastasis in cervical cancer through VEGFR-3 signaling pathway,which may be used as the valuable indicators for predicting lymph node metastasis and prognosis of cervical cancer.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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