Title: Experimental Study on Effects of a Small Non-peptidic CD4 Inhibitor J2 in Preventing Allograft Rejection
Abstract: Aim To investigate the effects of J2 on prevention of skin allograft rejection in mouse skin transplantation.Methods The C 57BL/6 and BALB/c were used as donors and recipients to establish a skin allograft model,and divided into 3 groups randomly.Group A,allograft control (this group was given placebo only);group B and group C,allograft groups,were treated with orally CsA and J2,respectively.The drugs were delivered for 12 days from the day of transplantation.Graft survival was assessed by Kaplan-Meier analysis.Fourteen days after transplantation,histological examination was performed to confirm the clinical diagnosis of rejection.Results The average transplant survival time in the allograft control (Group A) was (13.7±1.4)d.Treatment with J2 (Group C) led to a statistically significant prolongation of transplant survival to (17.7±2.4)d (P0.01),but compared with treatment with CsA (Group B) (18.2±2.1)d,there was no statistically significant difference between the two groups(P0.05).Fewer inflammatory cells were found in the skin allograft of J2 group.Conclusion These results showed that J2 could prevent skin graft rejection.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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