Title: Analysis of monitoring the plasma concentration of olanzapine in patients with schizophrenia
Abstract: Objective: To monitor the plasma concentration of olanzapine in patients with schizophrenia and investigate the relationship between clinical efficacy and plasma level of olanzapine. Method:65 patients with schizophrenia were treated with olanzapine for 8 weeks and the plasma concentration of olanzapine was measured by high performance liquid chromatography(HPLC),with doses of olanzapine,clinical efficacy and adverse effects being recorded. Results:The plasma concentration of olanzapine was 3.0 μg/L to 86.0 μg/L when patients took olanzapine 5~25 mg/day.There was a positive relationship between olanzapine doses and the plasma concentration(r=0.582).13 patients had plasma concentration10 μg/L,43 patients in range of 10~20 μg/L and 9 patients20 μg/L,with response rate 38.5%(5 cases),76.7%(33 cases) and 66.7%(6 cases),respectively.The patients with plasma concentration of olanzapine10 μg/L had higher response rate compared with those10 μg/L(P0.05).However,there was no significant difference in the response rate between patients with plasma concentration in range of 10~20 μg/L and that20 μg/L(P0.05).Significant differences appeared in adverse effects among the three groups,with 2 patients(15.0%) in10μg/L group,23 patients(53.0%) in range of 10~20 μg/L group and 8 patients(89.0%)in20 μg/L group(P0.01). Conclusion:The plasma concentration of olanzapine in range of 10~20 μg/L was suitable for the treatment of schizophrenia,with better efficacy and less adverse effects.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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