Title: Study of multiple sclerosis using diffusion weighted imaging
Abstract: Objective To investigate differences of apparent diffusion coefficient (ADC) values among different lesions, normal-appearing white matter of multiple sclerosis (MS) and white matter of normal volunteers. Methods Thirty-seven volunteers and 46 patients with MS underwent diffusion weighted imaging. The mean ADC was measured for T1 hypointense lesions, T1 isointense lesions, normal-appearing white matter regions and white matter regions of normal volunteers, respectively. Then differences of ADC values among these different regions were determined. Results The mean ADC values were 1.384×10 -3 mm 2/s for T1 hypointense lesions, 0.977×10 -3 mm 2/s for T1 isointense lesions, 0.762×10 -3 mm 2/s for normal-appearing white matter of MS, and 0.744×10 -3 mm 2/s for white matter of normal volunteers, respectively. Significant differences in ADC were observed among all groups ( P 0.01 for all comparisons). Conclusion Diffusion weighted imaging is able to identify different MS lesions and to detect diffuse abnormalities in the normal-appearing white matter of MS patients.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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Cited By Count: 1
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