Title: Rebound hypertension following withdrawal of tizanidine
Abstract: A 69-year-old woman with hypertension received oral tizanidine for muscle spasm due to traumatic brain injury.Her blood pressure was 135-174/73-90 mm Hg and heart rate was 60-80 beats/min before using the medicine.The dosage of tizanidine was increased to 4 mg thrice daily and,on day 2,her heart rate decreased to 45 beats/min.Tizanidine was stopped.The next day,her blood pressure was 180/100 mm Hg and heart rate was 120 beats/min.Captopril and nifedipine were given to adjust blood pressure and heart rate,but the effect was not good.Tizanidine 2 mg was given.About an hour later,her blood pressure was 124/69 mm Hg and heart rate was 65 beats/min.Twenty days later,tizanidine 2 mg was given again for hypermyotonia of lower extremity.Half an hour later,her blood pressure decreased to 60/40 mm Hg.Metaraminol was given and then the blood pressure returned to normal.Her blood pressure increased to 180/100 mm Hg again on the following day.The blood pressure tended to be stable gradually by concomitant use of amlodipine besylate,irbesartan,captopril and nifedipine.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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