Title: Correlative factors of blood pressure variability and morning blood pressure surge in elderly hypertensive patients
Abstract: ObjectiveTo observe blood pressure variability (BPV) in the elderly by ambulatory blood pressure monitoring (ABPM) and evaluate the relationship between morning blood pressure surge (MBPS) and other cardiovascular risk factors.MethodsFrom January 1, 2002 to December 31, 2010, 502 hypertensive inpatients and outpatients who underwent ABPM in the cardiovascular medicine department of the First Affiliated Hospital of SUN Yat-sen University were retrospectively studied.They were divided into four groups according to the ages: group 65-70(n=188), group 70-75 (n=141), group 75-80 (n=101) and group≥80 (n=72).Another 199 hypertensive patients aged less than 65 were enrolled as control group.Indexes of BPV and MBPS were calculated. The SBP of MBPS was calculated as follows: MBPS mean systolic blood pressure (SBP) in two hours after awakening-lowest nighttime systolic blood pressure (nSBP).Multi-factor statistical methods were used to evaluate the relationship between SBP of MBPS and other cardiovascular risk factors, such as age, gender, diabetes, smoking intensity and duration, body mass index (BMI), heart rate and blood pressure rhythm.Results①In the population aged over 65, the SBP of MBPS of group 75-80 was the highest(29.0±13.4)mm Hg, while that of group≥80 was the lowest (15.9±8.6)mm Hg.The difference was statistically significant (P0.05). ②Compared with those of the other four groups, the standard deviation and variation coefficient of 24 h systolic blood pressure (24hSBP), 24 h diastolic blood pressure (24hDBP), daytime systolic blood pressure (dSBP), nSBP, and nighttime diastolic blood pressure (nDBP) in group ≥80 were significantly higher, but the differences in the standard deviation and variation coefficient of daytime diastolic blood pressure (dDBP) had no statistical significance.③SBP of MBPSof patients whose BMI 18.5-25.0, 25.0-30.0, and ≥30 kg/m2 were higher than that of those whose BMI were 18.5 kg/m2(P0.01).Furthermore, the SBP of MBPS of the patients who had a smoking history of no more than 30, 31 to 40, 41 to 50, and over 50 years was higher than that of the non-smoking patients (P0.01). ④Multiple linear regression analysis showed that BMI, smoking duration and circadian pattern of SBP affected the SBP of MBPS (P0.01).ConclusionsBPV and SBP of MBPS increase with age in the elderly hypertensive patients, and the BMI, smoking duration and circadian pattern of SBP were the influencing factors.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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Cited By Count: 1
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