Title: Research advancement of placental 11β-HSD in Pathological Pregnancy
Abstract: Pathological pregnancy including fetal growth restriction(FGR),preeclampsia,gestational diabetes mellitus(GDM),is a disease with serious threat to maternal and fetal health.An in-depth study on the pathogenesis of pathological pregnancy will help to achieve a better clinical diagnosis and treatment.During human pregnancy,placenta secretes a number of 11β-hydroxysteroid dehydrogenase(11β-HSD),which is thought to be relevant with pathological pregnancy.There are two subtypes of 11β-HSD:11β-HSD1 and 11β-HSD2.The placental 11β-HSD2 serves as a functional barrier to protect the fetus from excessive exposure to high levels of maternal cortisol to insure the normal fetal growth and development.The reduction of 11β-HSD2 expression and activity may correlate with FGR.11β-HSD2 activity is reduced in preeclampsia;vice versa,preeclampsia can further reduce 11β-HSD2 activity.Enhanced 11β-HSD1 activity correlates with insulin resistance and may contribute to GDM.Therefore,regulation of the placental 11β-HSD activity will be one of the important measures for the treatment of pathological pregnancy.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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