Title: Protective effect of shenmai injection on lipid peroxide of kidney following hind limb ischemia reperfusion
Abstract: Objective To investigate the lipid peroxide of kidney following hind limb ischemia- reperfusion and the protective effect of shenmai injection.Methods 24 rabits were randomly divided into sham group,ischemia-reperfusion group and ischemia-reperfusion treated with shenmai injection group.The samples of every group were undertaken in 4h of reperfusion after 4h ischemia.The content of MDA and the activity of SOD in plasma (including IKB and OKB) and in the kidney tissue were measured.The content of creatinine in serum was observed.Results The content of MDA increased significantly in group I/R compared with group sham and the activity of SOD decreased(P0.05), while MDA decreased and SOD increased in group I/R+SMI compared with those of group I/R.The level of MDA in plasma of OKB was higher than that in plasma of IKB(P 0.05),and the activity of SOD was lower(P0.01)in group I/R;In group sham and I/R+SMI,the levels of MDA and the activities of SOD in plasma of OKB were not obviously different from IKB.The content of Cr in serum of group I/R increased significantly compared with group sham, but decreased in group I/R+SMI compared with group I/R and higher than group Sham.Conclusions Lipid peroxide of kidney is caused by limb ischemia reperfusion.Shenmai injection performs protective effect on lipid peroxide of kidney after limb ischemia reperfusion.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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