Title: Jiuweirougan Granule in the Treatment of Chronic Hepatitis B with Hepatic Fibrosis:A Double-Blind Randomized Controlled Study
Abstract: Objective To assess the safety and therapeutic effect of Jiuweirougan grandule on chronic hepatitis B with hepatic fibrosis.Methods A double-blind,double dummy and randomized controlled method was adopted.Ninety-six patients from February to August 2007selected by including and excluding criteria were distributed randomly in accordance with the 3:1ratio into the test group(n=72,treated with Jiuweirougan 10g,two times per day)and the control group(n=24,treated with Biejiaruangan 4tablets,three times per day).The period of treatment for both groups lasted for half a year.Results A total of 66cases in the test group and 21cases in the control group completed the experiment.The results of per-protocol population(PPS)suggested that the accumulated score of B ultrasound and symptom decreased 0.50±1.04and 8.61±3.62in the test group and 0.32±1.01and 8.63±3.15in the control group,respectively.The score decreased remarkably compared with pre-treatment(P 0.05).There was no significant difference between the two groups(P0.05).For serum liver fibrotic parameters,all parameters except laminin(LN)in the test group decreased remarkably compared with pre-treatment(P0.05).But in the control group,besides typeⅢ procollagen(PCⅢ)decreased remarkably(P0.05),other parameters showed no obvious changes.There was no significant difference between the two groups(P0.05).At the same time,no obvious adverse effect was found in the two groups.The incidence of adverse reactions was 5.56% and 4.17%respectively.Conclusion Jiuweirougan granule may improve the syndrome and part of fibrotic index of chronic hepatitis B with fibrosis,and the effect is equal to that of Biejiaruangan with good security.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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