Title: Determination of Pharmacokinetics and Bioavailability of Fluconazole by HPLC
Abstract: Objective To determine the pharmacokinetic and bioavailability of fluconazole.Methods Samples were detected by HPLC.The Chromatog.Conditions included:a Kromail C18 reversed-phase column(4.6 mm×250 mm),a acetonitrile-0.01 mol/L phosphate buffer(78∶22) mobile phase,and UV detection at 260 nm.Results Pharmacokinetic parameters of test fluconazole:Cmax(27.314±5.13)μg/mL,Tmax(1.75±0.26)h,t 1/2(Ke)(28.84±4.78)h,AUC0→96(883.55±126.08)μg/mL·h-1,AUC0→∞(956.64±137.33)μg/mL·h-1 Control fluconazole:Cmax(26.730±3.47)μg/mL,Tmax(1.72±0.26)h,t 1/2(Ke)(26.90±4.63)h,AUC0→96(929.92±155.84)μg/mL·h-1,AUC0→∞(985.35±162.19)μg/mL·h-1.Conclusion It appeared that the test pharmaceutical preparation and control preparation had no marked differences in Cmax,Tmax and AUC0→∞.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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