Title: CNE-2Z, A HUMAN NASOPHARYNGEAL CARCINOMA CELL LINE WITH A HIGH NUMBER OF EPIDERMAL GOWTH FACTOR (EGF) RECEPTORS, IS GROWTH INHIBITED BY EGF
Abstract: Epidermal growth factor (EGF) , a hormone-like cytomodulatory fact-tor, has been noted to stimulate the prolliferation of a variety of normal and malignant cells, We report here that CNE-2Z, a human poorly differentiated nasopharyngeal carcinoma cell line with a high number of EGF receptors(1.3× 10 5 /cell), is growth inhibited by EGF. The growth of CNE-2Z cells was mildly stimuiated by EGF under concentrations of 10-9 to 10-11 M and was significantly inhibited by EGF at concentrations greater than10-8 M, while, under the serum containing conditions employed, A431 cell line was growth inhibit, ed by EGF at concentration of 10-9M The results suggest that CNE- 2Z is growth inhibited by high concepntration of EGF and the inhibitory effect may be not independent on the number of EGF receptors.
Publication Year: 1991
Publication Date: 1991-01-01
Language: en
Type: article
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