Title: Correlation analysis of carotid atherosclerosis and left ventricular hypertrophy on chronic hemodialysis patients
Abstract: Objective:Accelerated atherosclerosis is common in chronic haemodialysis(HD) patients.In this study, we aimed to investigate the relationship between left ventricular hypertrophy (LVH) in HD patients and carotid atherosclerosis. Methodology:Forty-eight patients with maintenance HD were enrolled in this study. Their biochemical parameters, including BUN, creatinine, albumin, haemoglobin, and C-reactive protein were examined by routine methods. The anatomy, hemodynamics, atheromatous plaque and intima thickness (IMT) of carotid were measured by high resolution B-mode ultrasonography. The left ventricular diameter (LVD), left atrial diameter (LAD) left ventriadar mass index ( LVMI ), left ventricular posterior wall thickness (LVPWT), interventricular septal thickness (IVST), and left ventricular ejection fraction (LVEF) were also detected by ultrasonic cardiography. Results:The LVH was detected in 37 of the patients (77%). The plaque-positive was detected in 28 of the patients (58%). The plaque-positive patients had higher LVMI (P0.001), higher levels of serum cholesterol (P0.01), and low density lipoprotein cholesterol (P0.05) and thicker IMT (P0.01) than that in plaque-negative patients. The LVH-positive patients had higher LVMI(P0.05)and IMT(P0.05), and higher prevalence rate of hypertention (P0.001) than that in LVH-negative patients. The LVMI was correlated with systolic blood pressure (P0.001), pulse pressure (P0.001), and hemoglobin levels (P0.01). Conclusion:The carotid atherosclerosis is associated with LVH in maintenance HD patients. Whether the treatment of atherosclerosis may cause regression of or even prevent LVH in HD patients remains to elucidate. [JP]
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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