Title: Advances in the study of peroxisome proliferator-activated receptorsδ
Abstract: Peroxisome proliferator-activated receptors (PPARs)are a group of well-studied nuclear re- ceptor isoforms.PPARs are intimately connected to cellular metabolism(carbohydrate,lipid and protein)and cell differentiation.PPARs are ligand-activated transcription factors,as well as being a group of nuclear receptor isoforms. Since PPARs were first reported in the 1990s, their biological functions in cellular metabolism, differentiation and disease relative effects have been thoroughly investigated.PPARs have three subtypes,PPARα,PPARδ/βand PPARγ.The biological function and relationship to disease of PPARδhave become the focus of research, with the discovery of a special selective agonist of PPARδ.PPARδis one of the main factors that regulate adipocyte differentiation and energy dissipation.Furthermore,PPARδalso partici- pates in the development of several diseases. PPARδagonists are expected to become effective drugs for treating metabolic syndrome.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot