Title: Detection of Interleulin-1β and Tumor Necrosis Factor a in Cerebrospinal Fluid in patients with Mild Cognitive Impairment
Abstract:Objective: To analyse the cerebrospinal fluid values of the interleulin-1β and tumor necrosis factor a in patients with mild cognitive impairment. Method: The levels of the interleulin-1β and tumor ne...Objective: To analyse the cerebrospinal fluid values of the interleulin-1β and tumor necrosis factor a in patients with mild cognitive impairment. Method: The levels of the interleulin-1β and tumor necrosis factor a were analyzed using ELISA in 32patients with MCI and in 15 age matched healthy controls. Result: Patients with MCI displayed significantly higher levels of interleulin-1β and tumor necrosis factor a compared with the healthy controls. Conclusion: These results suggest that premflammatory cytokines interieulin-1β and tumor necrosis factor a should be important factors in the neurodegeneration progress and the inflammation should significantly contribute to trandform MCI into AD. The detection of the level of the interleulin-1β and tumor necrosis factor a in CSF should be valuable to MCI early diagnosis and treatments.Read More
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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