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'https://openalex.org/W2385022256', 'https://openalex.org/W2381242538', 'https://openalex.org/W2379246114', 'https://openalex.org/W2374577170', 'https://openalex.org/W2373191023', 'https://openalex.org/W2371969823', 'https://openalex.org/W2369600396', 'https://openalex.org/W2369467424', 'https://openalex.org/W2369096833', 'https://openalex.org/W2358330703', 'https://openalex.org/W2356227505', 'https://openalex.org/W2349701709', 'https://openalex.org/W2348109116'], 'abstract_inverted_index': {'目的:评价2种匹伐他汀钙片在人体内的生物等效性。方法:20例男性健康志愿者随机交叉单剂量口服试验制剂和参比制剂,利用LC-MS/MS法测定匹伐他汀体内血药浓度。结果:试验制剂和参比制剂的主要药动学参数如下:AUC0-t分别为(180.2±37.6)μg.h.L-1和(182.6±36.1)μg.h.L-1;AUC0-∞分别为(190.0±38.1)μg.h.L-1和(189.6±37.4)μg.h.L-1;Cmax分别为(54.3±18.2)μg.L-1和(65.1±22.4)μg.L-1;tmax分别为(0.80±0.25)h和(0.78±0.26)h;t1/2分别为(13.4±4.5)h和(12.0±2.8)h;经方差分析和双单侧t检验显示,主要药动学参数无显著差异,以AUC0-t计算匹伐他汀钙片的相对生物利用度为(100.3±19.9)%。结论:试验制剂与参比制剂具有生物等效性。': [0]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2369739505', 'counts_by_year': [], 'updated_date': '2024-09-14T17:05:11.158703', 'created_date': '2016-06-24'}