Title: The association between 24 h ambulatory blood pressure and microalbuminuria in patients with type 2 diabetic nephropathy
Abstract: Objective To investigate the relationship between the 24 h ambulatory blood pressure and microalbuminuria in type 2 diabetic nephropathy patients.Methods 194 patients were divided into 4 groups according to Mogensen stage:normal albuminuria (U|Alb≤30 mg/24 h,n=71),microalbuminuria (U|Alb 30-300 mg/24 h,n=47),mass albuminuria (U|Alb≥300 mg/24 h,n=31) and kidney function insufficiency U|Alb≥300 mg/24 h and eGFR≤mL/(min·1.73 m2),n=43.The variation,circadian rhythm and the smoothness indexes of blood pressure in each group were examined,and the associations between them and microalbuminuria were analyzed.Results With the increase of urinary microalbumin and the decrease of renal function,24|hour,diurnal systolic and diastolic blood pressure increased significantly (24|hour mean systolic blood pressure:normal albuminuria group (125.4±14.6) vs kidney function insufficiency group (146.6±13.3)mm Hg,diastolic blood pressure:(66.9±8.9) vs (83.0±8.8)mm Hg,all P0.05,standard deviation of 24|hour systolic pressure increased from (9.3±2.2) to (11.9±4.8) mm Hg (P0.05),smoothness indexes of systolic and diastolic blood pressure decreased (the smoothness indexes of systolic blood pressure in four groups:1.82±0.3,1.75±0.3,1.64±0.2 and 1.56±0.2,all P0.05).Pearson correlation analysis showed that the variation of 24|hour blood pressure and blood pressure standard deviation were positively correlated with 24|hour urinary microalbumin (P0.01),while the percentage of systolic blood pressure during night and smooth index were negatively correlated with 24|hour urinary microalbumin(P0.05).Conclusion Impaired circadian rhythm and the increased fluctuations of blood pressure were presented in early diabetic nephropathy patients.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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