Title: Expression and biological significance of p73 and p63 in laryngeal squamous cell carcinoma
Abstract: Objective:To investigate the expression of p73 and p63 and their biological significance in laryngeal squamous cell carcinomas(LSCC).Methods: The expression of p73 and p63 in 47 cases of tumor tissues、adjacent and normal tissues were detected using in situ hybridization.Results: Percentage of p73 expression was 57.4%(27/47),29.8%(14/47)in tumor tissues and adjacent tissues respectively.In contrast,normal laryngeal tissues did not express p73.Overexpression of p73 was strongly associated with tumor grade,TNM stage and cervical nodal metastasis;Percentages of p63 expression were 91.5%(43/47),93.6%(44/47),57.1%(8/14)in tumor tissues,adjacent and normal tissues respectively.The expression of p63 was not related to any clinicopathological features.Conclusion: The detection of expression of p73 is helpful to identify biological behavior and predict the prognosis of patients with LSCC.p63 has less effect on biological behaviors of LSCC.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot