Title: Expression of eIF4E in Human Colorectal Cancer
Abstract: Objective To study the expression of Eukaryotic Initiation Factor 4E(eIF4E)in human colorectal cancer and its relationship to clinical pathologic feature.Methods The express of eIF4E in 60 cases with colorectal cancer were examined by immunohistochemieal assay.The normal tissue of adjacent to cancer and large intestine adenomas (20 cases)were served as a contral group.Results The positive expression rates of eIF4E in the colorectal cancer tissues,the normal tissues of adjacent to cancer,and the large intestine adenoma tissues were 91.7%,10%,and 90% respectively.Compared colorectal cancer tissue with the normal tissue of adjacent to cancer,there was a signifi- cant difference(P0.05);compared large intestine adenoma tissue with the normal tissue of adjacent to cancer, there was a significant difference(P0.05);The positive expression was associated with invasiveness depth,but not related to patients' gender,age,profession,family history,location of cancer,tumor size,histological differentiation, lymph node metastasis and Dukes'stage.Conclusion eIF4E was over-expressed in colorectal cancer.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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