Title: Experimental Studies of Disseminated Intravascular Coagulation Treated by Low Molecular Weight Heparin
Abstract: Objective To compare the anticoagulant effects of heparin and low molecular weight heparin in disseminated intravascular coagulation. Methods A model of disseminated intravascular coagulation was established by injecting Lipopolysaccharide in rabbits,and 19 rabbits were randomly divided into 3 groups, they were treated respectively by heparin(n=6), low molecular weight heparin(n=6), and normal saline. Activated partial thromboplastin time (APTT), platelets counts, FⅩ, antithrombin-Ⅲ and fibronogen were assayed 2h, 4h, 6h before and after iv Lipopolysaccharide. Histological observation was done.[WTHZ]Results The APTT was prolonged remarkably by heparin, low molecular weight heparin. The results showed that fibrinogen and platelets was remarkedly decreased and antithrombin-Ⅲ, FⅩ were consumpted in rabbits with disseminated intravascular coagulation, the exhaustion of coagulation factors Ⅹ and antithrombinⅢ were mended after anticoagulation therapy, The decrease of fibrinogen and platelets in heparin group was more obvious. Thromboembolism was found in the control group but not in treatment groups.Conclusion Low molecular weight heparin has prominent anticoagulant effects, and it may have more advantage in treatment disseminated intravascular coagulation.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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