Title: Expression and clinical significance of S100A4 protein in human thyroid carcinomas
Abstract:Objective To study the significance and expression of S100A4 protein in human thyroid gland carcinomas. Methods Immunohistochemistry method was used to detect the expression of S100A4 protein in 56 ca...Objective To study the significance and expression of S100A4 protein in human thyroid gland carcinomas. Methods Immunohistochemistry method was used to detect the expression of S100A4 protein in 56 cases of malignant thyroid gland carcinoma (thyroid papillary cancer in 30 cases, thyroid medullary cancer in 12, thyroid follicular cancer in 8, and anaplastic thyroid cancer in 3), 45 cases of benign thyroid gland tumor (thyroid adenoma in 15, nodular goiter in 15, and primary hyperthyroidism in 15), and 13 cases of normal thyroid gland tissues. Results No S100A4 protein was expressed in normal thyroid gland tissues. The positive expression rate of S100A4 was 83.9% (47/56) in the thyroid gland carcinoma (the intensity of S100A4 protein was “+” in 25 cases, “++” in 12 and “+++” in 10), and 11.1% (5/45) in the benign thyroid gland tumors (the intensity of S100A4 protein was “+” in the 5 cases). There was significant difference in the expression of S100A4 between thyroid gland carcinomas and benign and normal groups (P0.01). The expression of S100A4 was positively correlated with the clinical stage and lymph node metastasis (P0.01). The positive expression rate of S100A4 was 77.8% (28/36) at clinical stage Ⅰ-Ⅱ (the intensity of S100A4 protein was “+” in 22 cases, “++” in 4, and “+++” in 2), which was significantly lower than that at clinical stage Ⅲ-Ⅳ 95.0% (19/20, the intensity of S100A4 protein was “+” in 3 cases, “++” in 8, and “+++” in 8, P0.01). The positive expression rate of S100A4 was 100% (16/16) in the thyroid malignant carcinoma with lymphnode metastasis (the intensity of S100A4 protein was “++” in 8 and “+++” in 8 cases), which was significantly higher than that in the thyroid malignant carcinoma without lymph node metastasis 77.5% (31/40, the intensity of S100A4 protein was “+” in 25 cases, “++” in 4, and “+++” in 2, P0.01). No significant difference was detected in positive rate and the intensity of the expression of S100A4 protein among the tumors with different pathological types. Conclusions S100A4 protein plays an important role in the proliferation and metastasis of thyroid cancer. The intensity of the expression of S100A4 protein can be used to evaluate the malignancy and prognosis of a thyroid cancer.Read More
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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