Title: Correlation Study between Urine Epidermal Growth Factor,Urine Microalbumin,β_2-Microglobulin and Early Renal Injury in Children with Henoch-Schonlein Purpura
Abstract: Objective To explore the correlation between urine epidermal growth factor (EGF),urine microalbumin(MA) and β2-microglobulin(β2-MG)and Henoch-Schonlein purpura (HSP)in children and explore sensitive laboratory indications of early renal damage for treatment of HSP.Methods Children involved in the experiments were divided into 3 groups,including HSP group:HSP were divided into pure purpura group,mixed pattern group and HSP nephritis(HSPN) group;normal control group;pretreatment and post-treatment group.EGF was detected by using double-antibody sandwich ABC-ELISA,MA and β2-MG detected by using radioimmunoassay.Results 1.HSP comparison of clinical classification found that the urine EGF[(173.90±112.53) μg/L vs (89.22±40.21) μg/L,(132.96±56.41) μg/L],MA[(46.34±18.49) mg/L vs (12.30±6.73) mg/L,(24.31±12.66) mg/L] and β2-MG[(0.52±0.39) mg/L vs (0.26±0.18) mg/L,(0.35±0.25) mg/L] level in HSPN group was higher than those in other groups(Pa0.05).2.The 3 indexes of post-treatment group were lower than pretreatment group and control group[EGF:(122.16±63.71) μg/L vs (59.13±11.60) μg/L,(24.74±8.75) μg/L;MA:(43.09±10.46) mg/L vs (12.94±5.73) mg/L,(6.12±3.91) mg/L;β2-MG:(0.45±0.25) mg/L vs (0.29±0.16) mg/L,(0.19±0.12) mg/L](Pa0.05);post-treatment group were higher than control group(P0.05),show statistical significance.3.Comparison of abnormity ratio in early period of 73 HSP children,serum BUN/Cr 13 cases (17.81%),urine routine test 22 cases(30.14%),BUN/Cr plus urine routine test 35 cases(47.95%),urine β2-MG 49 cases(67.12%);MA 53 cases(72.60%);EGF 67 cases(91.78%),EGF,MA,β2-MG respectively compared with BUN/Cr,urine routine test,BUN/Cr plus urine routine test show statistical significance(Pa0.05).4.The correlation coefficients among EGF,MA and β2-MG were respectively(r=0.444,0.426 Pa0.05).Conclusion EGF may involve in the development of HSP,urine EGF,MA and β2-MG are sensitive markers of renal damage in early stage of HSP patients.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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