Title: Target Controlled Infusion Propofol Combined with Epidural Anesthesia during Radical Gastrectomy in Patients with Gastric Cancer
Abstract: Objective To evaluate the effect of target controlled infusion(TCI) propofol combined with epidural anesthesia on the circulatory function, electroencephalograph, stress response during radical gastrectomy in patients with gastric cancer. Methods 30 patients with gastric cancer, were divided randomly into TCI propofol/fentanyl group(group T) and TCI propofol combined with epidural anesthesia(group T+E). In group T+E epidural was performed at T\-\{8~9\} and epidural catheter was placed and 0 5% ropivacaine was given before induction of general anesthesia. Hemodynamics and electroencephagram were monitored and intraoperative awareness, postoperative, restlessness, anesthetic dosage and time for emergence and orientation were recorded, also the concentrations of blood glucose, serum insulin, cortisol were determined at pre\|operation, induction, skin incision, exploration and end of the surgery. Results Total dose of propofol was statistically lower in group T+E than that group T(P0 05), same was the standardized unit dose of propofol, postoperative restlessness in group T+E significantly lower than in group T. BIS and SEF levels in both groups from induction to surgery over were significantly lower than those in pre\|induction, but there were unsignificantly between groups during whole procedures. The awakening time in two groups were similar, MAP in both groups after induction were significantly lower than in pre\|induction. The hemodynamics in group T+E was more stable than that in group T at exploration after surgery and extubation. The increase in cortisol was significantly greater in group T than in group T+E after surgery. There was no significant change in insulin. \{Conclusion\} Target controlled infusion propofol combined with epidural anesthesia during radical gastrectomy in patients with gastric cancer has the advantages of less propofol, rapid emergence, less postopertive restlessness, less stress response, more stable blood pressure and more accurate adjustment of depth of \{anesthesia\}.
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
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