Title: Effect of nerve growth factor on the expression of lung Muc5ac in asthma rats
Abstract: Objective To explore the effect of nerve growth factor(NGF) on lung Muc5ac expression in OVA-induced asthma rats.Methods Totally 27 SD rats were randomly divided into three groups:control group,asthma group and NGF group(treated with NGF).After 24 hours of treatment,the rats were anatomized and the express of lung Muc5ac were determined by immuno-histochemical staining.Results The expression of lung Muc5ac(expressed with positive areas,μm 2) were 501.8±270.6,1330.2±662.9 and 2033.9±892.3 separately in control,asthma and NGF group.Conclusion The expression of lung Muc5ac increased in asthma rats.NGF may play an important role in worsening airway inflammation of the rats.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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