Title: Protective activity of human erythropoietin against renal ischemia-reperfusion injury
Abstract: Objective To study the protective effect of erythropoietin (Epo) on renal ischemia-reperfusion (I/R) injury, following hemorrhagic shock in rats. Methods The rat model of renal I/R injury following hemorrhagic shock was established. Thirty-six SD rats were divided into three groups: control group (group 1, n=12), shock group (group 2, n=12), and Epo treatment group (group 3, n=12). Plasma malondialdehyde (MDA), Cr, blood urea nitrogen (BUN), tissue SOD, and IL-6 of rats in the three groups were observed. Re-sults Plasma MDA, Cr, BUN, and tissue IL-6 of Epo group were significantly lower than those of shock group, but SOD was significantly higher compared with shock group. Conclusion Epo has a protective effects on renal I/R injury following hemorrhagic shock in rats because it can increase SOD and decrease IL-6.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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