Title: EXPRESSION OF MATRIX METALLOPROTEINASE-2,TISSUE INHIBITOR OF METALLOPROTEINASE-1 AND TISSUE INHIBITOR OF METALLOPROTEINASE-2 IN ASTROCYTOMA
Abstract: ObjectiveTo study the expressions of matrix metalloproteinase-2(MMP-2),tissue inhibitor of metalloproteinase-1(TIMP-1) and tissue inhibitor of metalloproteinase-2(TIMP-2) in astrocytoma and their relationship with the clinical biological behavior of the tumor.MethodsExpressions of MMP-2,TIMP-1 and TIMP-2 were detected in 52 cases of astrocytoma by immunohistochemical(SP) staining method.ResultsThe differences of the expressions of MMP-2,TIMP-1 and TIMP-2 in astrocytoma(WHO grade Ⅱ),anaplantic astrocytoma(WHO grade Ⅲ) and glioblastoma(WHO grade Ⅳ) were significant(H_c=(7.966-)10.353,P0.05).ConclusionThe expression of MMP-2,TIMP-1 and TIMP-2 are closely correlated with the development of the invasive activity of human astrocytoma.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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