Title: C-MITOTIC EFFECTS OF COLCEMID (COM) ON MOUSE BONE MARROW CELLS
Abstract:Colcemid (COM) was tested for induction of increase of mitotic indices (MI) and c-mito-tic effects in bone marrow celis of male(101/E 1×C 3 H/E 1) F1 mice post single injection (i.p.). The doses of 1 ...Colcemid (COM) was tested for induction of increase of mitotic indices (MI) and c-mito-tic effects in bone marrow celis of male(101/E 1×C 3 H/E 1) F1 mice post single injection (i.p.). The doses of 1 mg/kg of COM were used and sampled at 2,6,10,14 and 18 hour. At 2 h post COM treatment, the MI and c-mitotic effect reached the highest, then decreased from 6 h to 18 h. At 18 h, the Mis decreased to (1 mg/kg) or significaatly below(3 mg/kg) the control level respectively; whereas, the corresponding frequencies of cells in class C-E were still significantly higher than in the controls. The possible mechanism by which COM induces increase of MI and the correalation between c-mitotic effects and induction of aneupoidy were discussed.Read More
Publication Year: 1996
Publication Date: 1996-01-01
Language: en
Type: article
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