Title: EFFECTS OF ENALAPRIL ON MYOCARDIAL APOPTOSIS IN RATS WITH HEART FAILURE
Abstract: Objective To investigate the relationship between myocardial remodeling and apoptosis, and the mechanism of heart failure(HF) in rats with chronic pressure-overload HF treated with enalapril. Methods Thirty rats were randomly divided into heart fai- lure group (HF, n =12), enalapril-treated group (treated group, n =12), and control group ( n =12). The rat model of chronic pressure-overload HF was induced by transverse abdominal aortic constriction. Six weeks after the constriction, the rats in the treated group were la- vaged with enalapril of 10 mg/(kg·d), and those in the other two groups with equal amount of normal saline. Twelve weeks after the constriction, the rats were killed and the hearts removed after the measurement of haemodynamic parameters. The left ventricles and heart were dissected and weighed, respectively. Apoptosis was assessed with TUNEL. Results Compared with the rats in the control group, the HF rats showed a more significant systolic dysfunction ( F=2.80,q= 2.49 , P 0.05), more myocardial apoptosis ( F=98.98,q=12.43, P 0.01). Enalapril treatment reduced myocardial apoptosis ( F=98.98,q=5.19,P 0.01) and improved LV remodeling ( F=49.34,q= 7.56 ,P 0.01). Conclusion Myocardial apoptosis is one of important factors of systolic dysfunction. Enalapril improves LV remodeling by reducing myocardial apoptosis and prevents the progress of HF.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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