Title: Effect of Moxibustion Combined with Medicine on Chronic Renal Failure Rats with Renal Fibrosis
Abstract: Objective: To observe the effect of moxibustion combined with medicine( Jianpi Qinghua Decoction) on CRF rats and discuss the function mechanism on renal fibrosis in perspective of inflammation. Methods: The rats model was set up by the resection of 5 /6 renal tissue with the method of Platt,and the rats were randomly divided into model group,control group,Jianpi Qinghua Decoctiongroup,moxibustion group and moxibustion combined with medicine group,and loading with high fat diet. The rats in control group and Jianpi Qinghua Decoctiongroup were administered valsantan andJianpi Qinghua Decoctionrepectively; the rats in moxibustion group was treated with moxibustion on renal acupoint and Zusanli once every other day; the rats in moxibustion combined with medicine group were administered Jianpi Qinghua Decoctioncombined with moxibustion on renal acupoint and Zusanli once every other day; the rats in sham operation group and model group were treated distilled water with intragastric asministration,and treated with moxibustion on renal acupoint and Zusanli once every other day,8 week for each group. The serum creatinine,Urea Nitrogen,IL-12,TNF-α,24 h urine protein,renal tissue IL-12,TNF-α,TGF-β,type I collagen and type Ⅳ collagen were tested,the pathological changes of renal tissue were observed. Results: Compared with sham operation group,the serum creatinine,urea nitrogen,and 24 h urine protein increased obviously in model group( P 0. 01); compared with model group,the serum creatinine decreased in Jianpi Qinghua Decoction group( P 0. 05); the serum creatinine,urea nitrogen and urine protein decreased obviously in moxibustion combined with medicine group( P 0. 05,P 0. 01),and the efficacy was better than that of control group,Jianpi Qinghua Decoctiongroup and moxibustion group,and the levels of IL-12 and TNF-αin serum( P 0. 01),the expression of TNF-α,TGF-β,type I collagen and type Ⅳ collagen in renal tissue( P 0. 01) decreased obviously.Conclusion: Through down regulating inflammation factors,moxibustion combined with medicine can inhabit inflammation status,improve renal function,intervention urine protein and delay the progress of CRF renal fibrosis.
Publication Year: 2015
Publication Date: 2015-01-01
Language: en
Type: article
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