Title: Magnetization transfer imaging study of idiopathic epilepsy at 3.0 T high field magnetic resonance scanner
Abstract: Objective: To study cerebral microstructure changes in patients with idio pathic epilepsy by magnetiza tion transfer imaging technique. Materials and Methods: Magnetization transfer imaging (MTI) were performed in thirty-two patients with idiopathic epilepsy and thirty-two healthy volunteers. MTI data were analyzed using voxel-based analyses of whole brain in statistical parametric mapping software (SPM2). Two-sample t-test was used to compare with two groups. Correlation between MTR and the illness duration was analyzed. The differences of P0.05 would be considered as statistical significance. Results: Compared with normal control group, MTR reduction areas were mainly located in bilateral middle frontal gyrus, anterior cerebellar lobe, right medial prefrontal, paracentral lobule, superior frontal gyrus and left inferior parietal lobule (P0.05). Negatively correlation was found in the occipital lingual gyrus, fusiform gyrus and left posterior lobe of cerebellum between MTR and the ill ness duration. Conclusions: MTI can detect the potential neuropathological changes of idiopathic epilepsy, and provide a theoretical basis for pathophysiological mechanism in epilepsy.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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