Title: Reorganization of motor function in patients with brain tumors as revealed by fMRI combined with an alternating movement task
Abstract:Objective To characterize reorganization of motor function in patients with brain tumors adjacent to the central sulcus by using functional MRI (fMRI). Methods Fourteen patients with brain tumors near...Objective To characterize reorganization of motor function in patients with brain tumors adjacent to the central sulcus by using functional MRI (fMRI). Methods Fourteen patients with brain tumors nearby the central sulcus and 6 normal volunteers underwent fMRI while they performing alternating unilateral finger-to-thumb opposition movements. The activated map for each unilateral hand movement was generated by cross correlation analysis following routine fMRI data pre-processing. The location and number of the activated voxels in both sides of cerebral and cerebellar hemisphere were then compared between the normal group and the patient group. Results For healthy subjects, unilateral hand, either right or left, movement, elicited activations mainly in the contralateral hemisphere and ipsilateral cerebellum. For the patients, while activation for the unaffected hand was essentially identical to that in the healthy subjects, the activation pattern during movement of the affected hand significantly changed, which includes compensational activation of primary motor area (M1) in the tumor unaffected hemisphere along with decreased activation in M1 in the affected hemisphere, increased activation in supplemental motor area (SMA) and other secondary regions, and bilateral cerebella activation. Conclusion With an alternating hand movement task, the present fMRI study not only demonstrated the displacement and distortion of the M1 in the tumor affected hemisphere, but also revealed a new pattern of functional reorganization, which appears to involve a distributed network throughout the whole brain.Read More
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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Cited By Count: 1
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