Title: Analysis on related factors of prenatal screening of chromosomal abnormality karyotype in advanced maternal age pregnant women
Abstract: Objective: To explore the relationship between chromosomal abnormality of advanced maternal age pregnant women and related factors of prenatal screening,in order to reduce the probability of invasive prenatal diagnosis among advanced maternal age pregnant women,avoid iatrogenic abortion and provide information for genetic counseling and prenatal diagnosis. Methods: A total of 705 advanced maternal age pregnant women undergoing prenatal fetal chromosome examination or neonatal chromosome examination after delivery were analyzed retrospectively,then they were divided into direct invasive prenatal diagnosis group and prenatal diagnosis group; the detection rates ofchromosomal abnormality karyotype in the two groups were compared; the pregnant women in prenatal screening group were divided into group A( 93 pregnant women with high risk of maternal serological screening),group B( 70 pregnant women with high risk of prenatal ultrasonic screening) and group C( 215 pregnant women with high risk of maternal serological screening combined with prenatal ultrasonic screening); the detection rates of chromosomal abnormality karyotype in the three groups were compared. Results: Among 705 pregnant women,37 pregnant women were found with fetal chromosomal abnormality karyotype,the incidence rate was 5. 24%; the detection rates of chromosomal abnormality karyotype in group A and group B were 2. 15%( 2 /93) and 1. 42%( 1 /70),respectively,which were statistically significantly lower than that in group C( 14. 41%,31 /215)( P 0. 01); among the pregnant women with low risk of screening,no fetus was found with chromosomal abnormality karyotype. Conclusion: Prenatal screening,including maternal serological screening and prenatal ultrasonic screening,can significantly improve the detection rate of fetal chromosomal abnormality; the detection rate of simple age factor chromosomal abnormality is low.
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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