Title: The bioequivalence of cefpodoxime oral suspension in healthy volunteers
Abstract: Objective: To study the bioequivalence of cefpodoxime oral suspensions in healthy volunteers. Methods: Twenty normal volunteers were enrolled in a randomized crossover study. Each volunteer was given a single oral dose of 200 mg cefpodoxime suspension (test preparation) or cefpodoxime tablet (reference preparation) for comparison. The plasma concentrations of cefpodoxime were determined by microbiologic assay. Results: The pharmacokinetic parameters of cefpodoxime suspension and cefpodoxime tablet were: tmax(2.8±0.5) and (3.1 ±0.5) h respectively; Cmax(2.85±0.55) and (2. 55±0.62) mg/L, t1/2 (2.2±0.2) and (2. 3±0.3) h; AUC0-t(16. 56±3.96) and (14.79±3.77) mg·h·L-1. The relative bioavailability of cefpodoxime oral suspension was 115.0% ± 27.1% . Conclusions: Cefpodoxime suspensions and cefpodoxime tablet are bioequivalent.
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
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